Celsion Corporation
May 4, 2010

Celsion Reports First Quarter 2010 Financial Results and Provides Business Update

Cash used in operating activities totaled $3.0 million for the first quarter 2010-

COLUMBIA, Md., May 4, 2010 /PRNewswire via COMTEX News Network/ -- Celsion Corporation (Nasdaq: CLSN), a leading oncology drug development company, announced today financial results for the first quarter ended March 31, 2010 and addressed the progression of the clinical trials of ThermoDox(R), Celsion's heat activated liposomal encapsulation of doxorubicin. ThermoDox(R) is currently being evaluated in the Phase III HEAT trial for the treatment of hepatocellular carcinoma (HCC) and in a Phase I/II trial for patients with recurrent chest wall breast cancer.

"We continue to make substantial progress recruiting patients into our Phase III HEAT trial for ThermoDox(R) and are on track to complete enrollment in the second half of this year with 331 patients enrolled to date," said Michael Tardugno, President and CEO of Celsion. "We have exceeded our goal of opening enrollment at 73 clinical trial sites world-wide. The Phase I/II DIGNITY trial of ThermoDox(R) in patients with recurrent chest wall breast cancer (RCW) also continues to advance. We are currently enrolling patients in the 50mg/m^2 dosing cohort, which will be used to determine our therapeutic dose."

Financial Results

For the first quarter ended March 31, 2010, Celsion reported a net loss from operations of $4.6 million, compared to a net loss from operations of $3.6 million for the same period of 2009. In the first quarter of 2010, the Company recorded a $1.6 million non-cash warrant liability charge. After effect of this non-cash charge, Celsion reported a net loss of $6.1 million, or $0.50 per diluted share, for the first quarter ended March 31, 2010 compared to a net loss of $3.6 million (after the effect of a $0.5 million noncash indemnity reserve benefit), or $0.35 per diluted share, in the same period of 2009. After the non-cash effect of the warrant liability charge of $1.6 million and other non-cash charges of $0.6 million related to stock based compensation and other expenses, and net balance sheet changes of $0.9 million, net cash used in operations totaled $3.0 million for the first quarter of 2010. The Company ended the quarter with a total of $10.4 million of cash, investments and other receivables and current assets.

Recent Company Highlights

The Company is holding a conference call to provide a business update and discuss the first quarter 2010 results at 11:00 a.m. Eastern Time on Tuesday, May 4, 2010. To participate in the call, interested parties may dial 1-888-600-4864 (Toll free U.S./Canada) or 1-913-312-1487 (International/Toll) and use Conference ID: 2068492 to register ten minutes before the call is scheduled to begin. The call will also be broadcast live on the Internet at http://www.celsion.com.

The call will be archived for replay on Tuesday, May 4, 2010 at 3:00 P.M. ET and will remain available until Tuesday, May 11, 2010. The replay can be accessed at 1-888-203-1112 (Toll free U.S./Canada) or 1-719-457-0820 (Toll/International) using Replay Pin: #2068492. The call will also be available on the Company's website, http://www.celsion.com, for 30 days after 3:00 P.M. on Tuesday, May 4, 2010.

About ThermoDox(R)

ThermoDox(R) in combination with hyperthermia has the potential to provide local tumor control and improve quality of life. ThermoDox(R) is a proprietary heat-activated liposomal encapsulation of doxorubicin, an approved and frequently used oncology drug for the treatment of a wide range of cancers including breast cancer. Localized mild hyperthermia (40-42 degrees Celsius) releases the entrapped doxorubicin from the liposome. This delivery technology enables high concentrations of doxorubicin to be deposited preferentially in a targeted tumor.

For primary liver cancer, ThermoDox(R) is being evaluated in a 600 patient global Phase III study at 60 clinical sites under an FDA Special Protocol Assessment. The study is designed to evaluate the efficacy of ThermoDox in combination with RFA when compared to patients who receive RFA alone as the control. The primary endpoint for the study is progression-free survival and enrollment is expected to be completed in the first half of 2010. For recurrent chest wall breast cancer, ThermoDox(R) is being evaluated in a pivotal Phase I/II open-label, dose-escalating trial that is designed to measure durable local complete response at the tumor site. Celsion expects to fully enroll the study in the third quarter of 2010. Additional information on these ThermoDox(R) clinical studies may be found at http://www.clinicaltrials.gov

About Celsion

Celsion is a leading oncology company dedicated to the development and commercialization of innovative cancer drugs including tumor-targeting treatments using focused heat energy in combination with heat-activated drug delivery systems. Celsion has research, license, or commercialization agreements with leading institutions such as the National Institutes of Health, Duke University Medical Center, University of Hong Kong, Cleveland Clinic, and the North Shore Long Island Jewish Health System.



    Investor Contact
    Marcy Nanus
    The Trout Group
    646-378-2927 or mnanus@troutgroup.com


For more information on Celsion, visit our website: http://www.celsion.com

Celsion wishes to inform readers that forward-looking statements in this release are made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Readers are cautioned that such forward-looking statements involve risks and uncertainties including, without limitation, unforeseen changes in the course of research and development activities and in clinical trials by others; possible acquisitions of other technologies, assets or businesses; possible actions by customers, suppliers, competitors, regulatory authorities; and other risks detailed from time to time in the Company's periodic reports filed with the Securities and Exchange Commission.


                          Celsion Corporation
                   Condensed Statements of Operations
                              (Unaudited)
              (in thousands except for per share amounts)


                                                        Three Months
                                                       Ended March 31,
                                                      2010           2009
                                                      ----           ----

     Operating expenses:
       Research and development                     $3,275         $2,943
       General and administrative                    1,299            688
                                                     -----            ---
           Total operating expenses                  4,574          3,631
                                                     -----          -----

     Loss from operations                           (4,574)        (3,361)

          Loss from valuation of warrant
           liability                                (1,570)             -
          Other (expense) income, net                   (1)            14

     Net Loss                                      $(6,145)       $(3,617)
                                                   =======        =======


    Basic and diluted net loss per common
     share                                          $(0.50)        $(0.35)
                                                    ======         ======

    Basic and diluted weighted average
     shares outstanding                             12,186         10,190
                                                    ======         ======




                              Celsion Corporation
                                 Balance Sheets
                  (in thousands except for per share amounts)

                                                     March 31,
                                                        2010     December
    ASSETS                                          (Unaudited)  31, 2009
                                                    -----------   --------
     Current assets
       Cash and cash equivalents                         $4,114     $6,924
       Short term investments available for sale          5,458      5,695
       Refundable income taxes                                -        806
       Prepaid expenses and other receivables               858        695
                                                            ---        ---
           Total current assets                          10,430     14,120
                                                         ------     ------

       Property and equipment                               497        537
                                                            ---        ---

     Other assets
       Deposits                                              90         97
       Other assets                                          49         51
                                                            ---        ---
           Total other assets                               139        148
                                                            ---        ---

    Total assets                                        $11,066    $14,805
                                                        =======    =======

    LIABILITIES AND STOCKHOLDERS' EQUITY
     Current liabilities
       Accounts payable - trade                          $2,304     $2,191
       Other accrued liabilities                          1,691      1,452
       Note payable - current portion                       112        108
                                                            ---        ---
           Total current liabilities                      4,107      3,751

       Warrant liability                                  2,392        822
       Other liabilities - noncurrent                       161        197
                                                            ---        ---
           Total liabilities                              6,660      4,770
                                                          -----      -----

     Stockholders' equity
       Common stock -$0.01 par value (75,000,000
        shares authorized; 12,978,417 and
        12,895,174 shares issued and 12,218,143 and
        12,134,900 shares outstanding at March 31,
        2010 and December 31, 2009, respectively)        130     129
       Additional paid-in capital                        95,539     95,035
       Accumulated other comprehensive income                79          -
       Accumulated deficit                              (88,265)   (82,052)
                                                        -------    -------
             Subtotal                                     7,483     13,112
       Less: Treasury stock - at cost                    (3,077)    (3,077)
                                                         ------     ------
           Total stockholders' equity                     4,406     10,035
                                                          -----     ------

    Total liabilities and stockholders' equity          $11,066    $14,805
                                                        =======    =======




SOURCE Celsion Corporation

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